| Rank | Team | Wins | Record |
| 1. | Miami Marlins, 2013 | 39 | 39-123 |
| 2. | Seattle Mariners, 2010 | 40 | 40-122 |
| 3. | Chicago Cubs, 1981 | 41 | 41-121 |
| 4. | Washington Senators, 1958 | 42 | 42-112 |
| 5. | Seattle Mariners, 2005 | 42 | 42-120 |
| 6. | Seattle Mariners, 2011 | 42 | 42-120 |
| 7. | Kansas City Royals, 1969 | 44 | 44-118 |
| 8. | New York Yankees, 1944 | 45 | 45-109 |
| 9. | Detroit Tigers, 1975 | 47 | 47-115 |
| 10. | Oakland A's, 1977 | 47 | 47-115 |
| 11. | Milwaukee Brewers, 2009 | 47 | 47-115 |
| 12. | Philadelphia A's, 1946 | 48 | 48-106 |
| 13. | St. Louis Cardinals, 1956 | 48 | 48-106 |
| 14. | Washington Senators, 1956 | 48 | 48-106 |
| 15. | Seattle Mariners, 1983 | 48 | 48-114 |
| 16. | Washington Nationals, 2007 | 48 | 48-114 |
| 17. | Washington Nationals, 2008 | 48 | 48-114 |
| 18. | Toronto Blue Jays, 2009 | 48 | 48-114 |
| 19. | Milwaukee Brewers, 2014 | 48 | 48-114 |
| 20. | Montreal Expos, 1969 | 49 | 49-113 |
| 21. | Boston Braves, 1946 | 50 | 50-104 |
| 22. | Minnesota Twins, 1981 | 50 | 50-112 |
| 23. | Atlanta Braves, 1986 | 50 | 50-112 |
| 24. | St. Louis Cardinals, 1940 | 51 | 51-103 |
| 25. | Philadelphia A's, 1943 | 51 | 51-103 |
| 26. | New York Mets, 1967 | 51 | 51-111 |
| 27. | Milwaukee Brewers, 1971 | 51 | 51-111 |
| 28. | Chicago Cubs, 1933 | 52 | 52-102 |
| 29. | Baltimore Orioles, 1959 | 52 | 52-102 |
| 30. | Seattle Pilots, 1969 | 52 | 52-110 |
| 31. | Chicago Cubs, 1970 | 52 | 52-110 |
| 32. | Milwaukee Brewers, 1975 | 52 | 52-110 |
| 33. | Seattle Mariners, 1977 | 52 | 52-110 |
| 34. | Toronto Blue Jays, 1978 | 52 | 52-110 |
| 35. | Montreal Expos, 1990 | 52 | 52-110 |
| 36. | Kansas City Royals, 1995 | 52 | 52-110 |
| 37. | Miami Marlins, 2012 | 52 | 52-110 |
| 38. | Toronto Blue Jays, 2012 | 52 | 52-110 |
| 39. | Minnesota Twins, 2013 | 52 | 52-110 |
| 40. | Pittsburgh Pirates, 1940 | 53 | 53-101 |
| 41. | Boston Braves, 1943 | 53 | 53-101 |
| 42. | Chicago White Sox, 1970 | 53 | 53-109 |
| 43. | Chicago White Sox, 1985 | 53 | 53-109 |
| 44. | Florida Marlins, 1993 | 53 | 53-109 |
| 45. | Cincinnati Reds, 2003 | 53 | 53-109 |
| 46. | Detroit Tigers, 2003 | 53 | 53-109 |
| 47. | Toronto Blue Jays, 2010 | 53 | 53-109 |
| 48. | Oakland A's, 2014 | 53 | 53-109 |
| 49. | Boston Braves, 1935 | 54 | 54-100 |
| 50. | New York Yankees, 1945 | 54 | 54-100 |